Abstract
A new fabrication of {[H 3 O][Cu 6 (tpta) 3 (DMA) 4 (COO)]∙12H 2 O∙7DMA} ( 1 ) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1 . Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery. KEY WORDS : Drug delivery, Release, Porous MOF Bull. Chem. Soc. Ethiop. 2017 , 31(3), 457-463. DOI: http://dx.doi.org/10.4314/bcse.v31i3.9
Highlights
Metal-organic frameworks (MOFs) have undergone rapid development as functional materials such as catalysts, luminescence materials and magnetic materials [1,2]
Férey and co-workers firstly proposed the use of porous MOFs as controlled delivery systems [1b]
We propose the development of 1 as drug carrier, which may exhibit excellent drug loading capacity taking advantage of its larger pore size and permanent porosity
Summary
Metal-organic frameworks (MOFs) have undergone rapid development as functional materials such as catalysts, luminescence materials and magnetic materials [1,2]. This method strongly depends on the loading capacity of the porous materials, as well their pore size and conformation [4].
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