Abstract
Only scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum IL-8 and MCP-1 concentration in unruptured intracranial aneurysm (UIA) patients (n = 25) compared to the control group (n = 20). IL-8 and MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF IL-8 concentration of UIA patients is significantly higher (p < 0.001) than that presented in the serum, which can indicate its local synthesis within central nervous system. CSF IL-8 concentration was also significantly related to aneurysm size, which may reflect the participation of IL-8 in the formation and development of brain aneurysms. IL-8 Quotient (CSF IL-8 divided by serum IL-8) in UIA patients was statistically higher compared to control individuals (p = 0.045). However, the diagnostic utility analysis did not equivocally indicate the diagnostic usefulness of the IL-8 Quotient evaluation in brain aneurysm patients. Nevertheless, this aspect requires further study.
Highlights
Intracranial cerebral aneurysms (IAs) occur in approximately 5% of the population [1,2]
cerebrospinal fluid (CSF) interleukin 8 (IL-8) concentration was higher, while serum IL-8 concentration lower in unruptured intracranial aneurysm (UIA) patients compared to the control group, but differences were not significant In UIA patients, CSF IL-8 median concentration was 3-fold higher compared to median serum concentration (p < 0.001)
Univariate linear regression analysis revealed that: (1) with an increase in IL-8 concentration in CSF by 10 pg/mL, the aneurysm size increases by 1.14 times; (2) with an increase in body mass index (BMI) by 1, the aneurysm size increases by 1.035 times (Table 5)
Summary
Intracranial cerebral aneurysms (IAs) occur in approximately 5% of the population [1,2]. Cerebral aneurysms are usually asymptomatic but associated with the risk of a life-threatening intracranial hemorrhage [8]. IAs are most often diagnosed only incidentally during magnetic resonance imaging (MRI) or computed tomography (CT) performed for a variety of reasons, like headaches or head injuries. It must be stressed, that a good portion of small aneurysms can escape visualization with standard MRI/CT, while still retaining potential for rupture and bleeding [9]. Unruptured intracranial aneurysms (UIAs) with a high estimated risk of rupture (i.e., of unfavorable location, size and structure) are secured by surgical clipping or by intravascular embolization. The UIAs with low estimated probability of rupture are often not qualified for obliteration because of the risk inherent to surgical intervention [10,11,12,13]
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