Abstract
Cats given dimethylsulfoxide intravenously exhale 3% of the administered dose as the volatile metabolite dimethylsulfide within 5 hours. The rate of respiratory excretion of dimethylsulfide appears to be limited by the rate of its metabolic production, rather than by respiratory factors. The liver does not appear to be a major site of the reduction of dimethylsulfoxide to dimethylsulfide because hepatectomy does not significantly affect the rate of dimethylsulfide excretion. Dimethylsulfoxide is reduced in vitro to dimethylsulfide by cysteine and glutathione, suggesting a nonenzymatic conversion.
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