Abstract
The rate of rejoining of γ-ray induced DNA strand breaks has been measured in diploid skin fibroblasts from normal subjects at early and middle passage through their invitro lifespan and compared to the rate of rejoining observed in cells from 4 patients with symptoms of the Hutchinson-Gilford Progeria syndrome of precocious aging. The rate of rejoining observed in middle passage diploid cells was less than that in cells in very early passage. The rate of rejoining in progeric cells varied markedly among cells from different patients but was significantly less than the rate in normal diploid cells. The reason for this decreased rate of DNA strand rejoining in progeric cells is not clear, but it may be related to accelerated invitro senescence which is observed in some progeric cell strains.
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