Abstract
1 JG Brown Cancer Center, University of Louisville, 417 CTR Building, 505 S. Hancock Street, Louisville, KY 40202, USA 2Division of Hematology/Oncology, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 3-055 Katz Group Centre for Pharmacy and Health Research, 113 Street 87 Avenue, Edmonton, AB, Canada T6G 2E1 3School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK 4National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseoung-D, Yuseong-G, Daejeon 305-701, Republic of Korea
Highlights
The Ras-association domain family (RASSF) proteins are tumor suppressor proteins whose importance to the development of cancer has become increasingly apparent over the last 12 years
While possessing no enzymatic activity, they appear to function as scaffolding molecules to regulate the activity of a surprisingly broad array of effectors. They are implicated in the regulation of a diverse range of biological functions including apoptosis, autophagy, cell cycle control, microtubule dynamics, and DNA repair
The RASSF1A gene may be unique in the family as it found to be frequently mutated in cancer cells
Summary
The Ras-association domain family (RASSF) proteins are tumor suppressor proteins whose importance to the development of cancer has become increasingly apparent over the last 12 years. They are implicated in the regulation of a diverse range of biological functions including apoptosis, autophagy, cell cycle control, microtubule dynamics, and DNA repair. Inactivation of RASSF genes in cancer involves epigenetic silencing of their promoters. The RASSF1A promoter appears to be the most frequently inactivated promoter yet detected in human tumors.
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