Abstract
The precise mechanism by which Ras proteins mediate mitogenic signaling remains obscure. We have identified the p53/p21Cip1 axis as an essential component of the Ras mitogenic pathway. Moreover, cells carrying an inactive p53/p21Cip1/Rb pathway sustain cell proliferation by inducing retroactivation of the MAPK signaling cascade in a Ras-independent manner.
Full Text
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call