Rare Primary Diffuse Large B-Cell Lymphoma of a Male Breast

Hani Alothaid,Saad Saeed Alamri,Mahmoud M Habibullah,Umama Yezdani,Mazen M Ghaith,Mohammad Gayoor Khan

doi:10.4236/crcm.2021.104012

Abstract

Background: Breast lymphomas are typical extranodal types of lymphoma, also known as Extranodal-lymphoma (ENL), which occur extremely infrequently, aggregating into a very small proportion of malignant breast tumors. The rarity of breast lymphomas is attributed to the scant lymphoid tissue content of the chest wall. Aims of Study: This case report is aimed at providing an up-to-date review of the literature on breast lymphomas for clinicians to, therefore, consider the possibility of this disease entity while treating a breast mass. Case Presentation: A case was reported of a 52-year man with chief mammary non-Hodgkin breast ENL when fine-needle aspiration cytology (FNAC) was not leading to a firm conclusion or result. Following an incisional biopsy, he was found to have a primary breast lymphoma. Later, the patient was diagnosed with the diffuse large B-cell type of lymphoma also known as non-Hodgkin’s Lymphoma (NHL). He had a complete reduction and disappearances of all the signs and symptoms of the disease after a course of neoadjuvant chemotherapy: Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (CHOP). CONCLUSION: Based on the above case presentation, it is vital for health care professionals and oncologists to recognize the disease by assessing the breast mass accurately with more entities so that proper diagnosis via core biopsy (incisional biopsy) can eliminate the PBL before further treatment is required.

Highlights

Primary breast lymphoma (PBL) is both a typical yet rare clinical entity: a very well-defined subcategory of non-Hodgkin’s Lymphoma (NHL)
Aims of Study: This case report is aimed at providing an up-to-date review of the literature on breast lymphomas for clinicians to, consider the possibility of this disease entity while treating a breast mass
Case Presentation: A case was reported of a 52-year man with chief mammary non-Hodgkin breast ENL when fine-needle aspiration cytology (FNAC) was not leading to a firm conclusion or result

Summary

Introduction

Primary breast lymphoma (PBL) is both a typical yet rare clinical entity: a very well-defined subcategory of non-Hodgkin’s Lymphoma (NHL). Several reports suggest that PBL represents 0.6% of all malignant breast tumors, 1.2% of all the NHL, and 2.1% of Extranodal-lymphomas (ENL) [1] [2] [3] [4] [5]. Most breast lymphomas are of the non-Hodgkin’s type, representing approximately 70% 90% of all PBL, while diffuse large B- cell lymphomas (DLBCL) constitute 46% 71% of all PBL [6]. (P-NHL) Primary-NHL is one of the most frequent and hematopoietic tumors of the breast [7]. Aims of Study: This case report is aimed at providing an up-to-date review of the literature on breast lymphomas for clinicians to, consider the possibility of this disease entity while treating a breast mass

The Case Presentation

Discussion

Findings

Conclusion

Alothaid et al DOI