Extranodal primary non hodgkin lymphoma of breast: Multimodal approach to diagnosis

Abstract

The primary Non-Hodgkin’s lymphoma of breast is rare. The primary lymphomas of breast are bilateral in younger age group and unilateral in older age group. We report a rare case of primary Non-Hodgkin’s lymphoma (NHL) diffuse large B cell type of right breast with multimodal approach for diagnosis. Features of undifferentiated carcinoma were seen on fine needle aspiration cytology, histopathology with gold standard method for diagnosis showed features of aggressive malignant diffuse large cell lymphoma. Immunohistochemistry positive for CD20, MUM1 and Bcl6 provided the evidence to the histopathological diagnosis and guided us towards the poor prognosis of the malignancy by subtyping. We compare the incidence of NHL of breast at our institute with the available literature. Keywords: Primary Non-Hodgkin’s lymphoma of breast, diffuse large B cell type, Fine needle aspiration cytology, Immunohistochemistry.