Abstract
Background Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. The disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Recurrence of KFD is reported rarely. Case Presentation. A 56-year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. The excision biopsy of the cervical lymph nodes confirmed the diagnosis of KFD, and she made a full recovery with improvement of symptoms, regression of cervical lymph nodes, and normalization inflammatory markers. One year after remission, she presented with similar clinico-biochemical profile, and repeat biopsy confirmed KFD. Conclusion Although the rate of recurrence of the disease is very low, the treating physician should consider the possibility and confirm it histologically.
Highlights
Kikuchi necrotizing lymphadenitis is a rare, benign, and selflimiting disease that is commonly associated with cervical lymphadenopathy and fever [1, 2]
Kikuchi–Fujimoto disease (KFD) is generally reported more common in women than men [5, 6]. e average age of people involved is less than 40 years and is more common in young people [6]
Arthritis, fatigue, and hepatosplenomegaly are reported [7]. e definitive diagnosis of this disease is made by excisional biopsy of the cervical lymph nodes and is based on histopathology [8]
Summary
Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. e disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. E disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. A 56year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. E excision biopsy of the cervical lymph nodes confirmed the diagnosis of KFD, and she made a full recovery with improvement of symptoms, regression of cervical lymph nodes, and normalization inflammatory markers. She presented with similar clinico-biochemical profile, and repeat biopsy confirmed KFD. The rate of recurrence of the disease is very low, the treating physician should consider the possibility and confirm it histologically
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
