Abstract
Rapidly Curing Chitosan Calcium Phosphate Composites as Dental Pulp Capping Agents
Highlights
Dental caries are the most prevalent yet preventable disease in both children and adults [1]
Human dental pulp stem cells were obtained from Lonza (Walkersville, MD, USA). 4,6-Diamidino-2-phenylindole, dihydrochloride (DAPI), Osteocalcin Monoclonal Antibody (OCG4) and Goat anti-Mouse IgG (H + L) highly cross-absorbed secondary antibody, AlexaFluor Plus 647 were all purchased from ThermoFisher (Waltham, MA, USA)
Hydroxyapatite whiskers were synthesized as the composite filler for these materials, due to their similarity to native calcium phosphate mineral and their desirable properties as a filler
Summary
Dental caries are the most prevalent yet preventable disease in both children and adults [1]. The most prevalent restorative methods for cavity treatment are amalgam and resin fillings. If a cavity becomes so severe that it threatens to infect the dental pulp, it may be necessary to apply a pulp capping agent to save the tooth. Many different materials have been used as pulp capping agents with various levels of success in forming a dentin bridge that seals the pulp. The gold standard for pulp capping is calcium hydroxide, which creates a necrotic layer of pulp that seals the vital tissue and stimulates the formation of a dentin bridge [9]. The materials presented here were designed to create a rapid curing, mechanically stable and biocompatible pulp capping agent
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