Rapid virus inactivation by nanoparticles-embedded photodynamic surfaces

Abstract

The persistent threat of viral epidemics poses significant risks to human health, highlighting the urgent need for antiviral surfaces to mitigate viral transmission through bioaerosols and surface contamination. However, there is still a scarcity of readily accessible antiviral coatings to address this critical concern. In this study, we demonstrate that photodynamic nanoparticle-embedded surfaces can swiftly inactivate both enveloped and non-enveloped viruses. We prepared core–shell structured methylene blue (MB)-loaded SiO2 nanoparticles with a high reactive oxygen species (ROS) yield (0.47 ± 0.02). The superior ROS production was maintained after modifying these nanoparticles onto air filter fibers, likely due to the prevention of aggregation-caused quenching effects. Three viruses, including both enveloped and non-enveloped types, were rapidly inactivated within just 12 min (>6 log units) under medium light intensity (660 nm, 30 mW/cm2). Mechanistic studies revealed that envelope glycoproteins are the primary targets for this rapid inactivation. Thus, photodynamic nanoparticle-embedded surfaces offer a straightforward and adaptable strategy in the fight against viral epidemics.