Abstract
A simple and rapid dispersive liquid-liquid microextraction (DLLME) method coupled with gas chromatography-mass spectrometry (GC-MS) for monitoring and determination of class 1 residual solvents, benzene (Bz), carbon tetrachloride (CT), 1,2-dichloroethane (1,2-DCE), 1,1-dichloroethene (1,1-DCE), 1,1,1-trichloroethane (1,1,1-TCE), in pharmaceuticals was developed and evaluated. The parameters affecting the extraction efficiency of analytes such as type and volume of extraction solvent, type and volume of dispersive solvent and ionic strength were investigated and optimized. 1-Octanol and methanol proved to be the most suitable extraction and dispersive solvents, respectively. The method showed linearity for 1,1-DCE, 1,1,1-TCE, CT, Bz and 1,2-DCE in the ranges of 0.001-80, 0.005-80, 0.002-80, 0.0001-40 and 0.001-80 µg/mL, respectively. The relative recoveries were in the range of 84-92, 87-98, 83-94, 89-98 and 87-96% for 1,1-DCE, 1,1,1-TCE, CT, Bz and 1,2-DCE, respectively. The obtained results showed that the proposed method can be used to monitor and determine class 1 residual solvents in pharmaceuticals.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
