Rapid growth of an atypical meningioma in association with cyproterone acetate use: Case report

Abstract

Meningiomas are extremely common intracranial tumours. When classified based on their histological appearance, the majority (approximately 80%) are World Health Organisation (WHO) Grade 1 benign tumours. A small percentage of meningiomas are atypical (WHO Grade 2) or anaplastic (WHO Grade 3), with higher-grade tumours demonstrating aggressive clinical and pathological characteristics. There is a well-recognised relationship between meningioma growth during periods of elevated circulating female sex hormones; this has been demonstrated in pregnancy or with the administration of exogenous synthetic hormones.