Absence of KLF6 gene mutations in human astrocytic tumors and cell lines.

Abstract

In most cases, theallelic losses involve loci along the entire chromosome, afinding in line with monosomy 10. LOH on chromosome 10may also be detected in anaplastic astrocytomas (WHO GradeIII) and diffuse astrocytomas (WHO Grade II), but is lesscommon than in glioblastomas and more frequently restrictedto partial losses.