Abstract
AbstractThe rapid detection of biomolecule levels in the human body is often required to monitor human health. Although swellable microneedle arrays are widely used to extract biomolecules in interstitial fluid in a minimally invasive manner, it takes 3–15 min to carry this out. Herein, we report the development of a microneedle sensor system for the rapid detection of biomolecules. By controlling the crosslinking sequence of methacrylated hyaluronic acid (MeHA) used in the microneedle array, we achieve a swelling ratio of approximately 600% in 30 s in vitro. Furthermore, an electrochemical measurement method is utilized to detect redox reaction of biomolecules extracted with the MeHA microneedle array and screen‐printed electrode. One can measure 1 × 10−6 m of dopamine in 3 s in vitro and with excellent selectivity in a solution of dopamine along with 100 × 10−6 m of L‐ascorbic acid and uric acid. Finally, ex vivo electrochemical analysis is performed on a gelatin phantom and porcine skin containing various concentrations of dopamine and can detect 10 × 10−6 m of dopamine within 30 s. Thus, the swellable hydrogel‐based microneedle array can be applied to biomolecule sensing in interstitial fluid within a few seconds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.