Rapid cardiac T1 mapping within two heartbeats

Elodie Breton,Leon Axel,Daniel Kim,Sohae Chung

doi:10.1186/1532-429x-13-s1-o107

Elodie Breton, Leon Axel + Show 2 more

Open Access

https://doi.org/10.1186/1532-429x-13-s1-o107

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Abstract

Late gadolinium enhancement (LGE) imaging is an important CMR method than can detect salvageable myocardium after myocardial infarction [1-2]. Recently, T2-weighted-imaging has gained a significant interest to assess myocardial edema [3]. However, clinical interpretation of T2-weighted-imaging could be hindered by surface coil effects which yield non-uniform signals. Multi-point T1 mapping approaches, such as Modified Look-Locker inversion recovery (MOLLI) [4], have been proposed to measure myocardial T1, but, as a multiple heartbeat acquisition, it may be sensitive to cardiac motion and arrhythmia. We propose to develop a 2-second cardiac T1 mapping pulse sequence for assessment of myocardial edema (pre-contrast) and infarction (post contrast) in patients with acute myocardial infarction.

Highlights

Late gadolinium enhancement (LGE) imaging is an important CMR method than can detect salvageable myocardium after myocardial infarction [1,2]
Myocardial T1 measured using the proposed rapid method were linearly correlated with T1 measured using the multi-point T1 method (Fig. 1, slope=0.99, Methods The proposed T1-mapping acquisition consists of 2 TurboFLASH images with centric k-space ordering: proton density-weighted (PDw) image in the first heartbeat and saturation recovery (SR) T1w acquisition in the second heartbeat
The T1w-image was normalized by the PDw image to correct for unknown equilibrium magnetization and receiver coil sensitivity

Summary

Introduction

Late gadolinium enhancement (LGE) imaging is an important CMR method than can detect salvageable myocardium after myocardial infarction [1,2]. Purpose To develop and validate a cardiac T1-mapping technique. Imaging parameters included: FOV=350mm×272mm, matrix=144×112, TE/TR=1.2/ 2.4ms, flip angle=10°, in-plane resolution=2.4mm×2.4mm, GRAPPA ~1.65, temporal resolution=162ms, and receiver bandwidth=990Hz/pix.

Results

Conclusion