Abstract
Microwave irradiation has been used to enhance the reaction yields and selectivities for organic transformation. In this paper, microwave irradiation (MW) was investigated for the environmentally benign synthesis of benzoxazoles through the cyclization of 2-aminophenols and benzaldehydes using deep eutectic solvent (DES) as a catalyst. The [CholineCl][oxalic acid] was easily synthesized from choline chloride with oxalic acid and used without further purification. [CholineCl][oxalic acid] catalyzed the synthesis of benzoxazoles to produce the desired product in a good to excellent conversion and selectivity under MW irradiation. The presence of [CholineCl][oxalic acid] helps to promote the rapid heating transfer from microwave irradiation into the reaction mixture. The [CholineCl][oxalic acid] can be recovered and reused several times without a considerable degradation in catalytic activity.
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