Abstract
Piroxicam (PX) as a nonsteroidal anti-inflammatory drug (NSAID) can be effectively used for anti-inflammatory and analgesia. However, overdoses may induce side effects such as gastrointestinal ulcers and headaches. Therefore, the assay of piroxicam has considerable significance. In this work, nitrogen-doped carbon dots (N-CDs) was synthesized for PX detection. The fluorescence sensor was fabricated by hydrothermal method with plant soot and ethylenediamine. The strategy exhibited a detection range of 6–200 μg/mL and 250–700 μg/mL with the limited detection of 2 μg/mL. The mechanism of the PX assay base on the fluorescence sensor was the process of electron transfer between the PX and N-CDs. The assay subsequently demonstrated could be successfully used in actual sample. The results indicated that the N-CDs could be a superior candidate nanomaterial for piroxicam monitoring in the healthcare product industry.
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