Abstract
Raised Serum Transaminases during Treatment with Pegylated Interferon for Chronic Hepatitis C
Highlights
Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin
Since 1999, the current standard therapy consists of combination therapy of pegylated interferon and ribavirin with sustained virological response (SVR) rates ranging between 42-82% depending on the viral genotype [2]
Viral kinetic studies reveal that most patients with chronic hepatitis C (HCV) infection who achieve an SVR following standard treatment, clear Hepatitis C (HCV) from serum within a few weeks [3,4]
Summary
219 patients with chronic hepatitis C, genotypes 2 and 3, were treated between 2005 and 2011 following the same protocol. For the 7 patients presented in this paper, the initial liver screen revealed chronic hepatitis C infection only. The same liver screen was repeated following the transaminase rise during the treatment period and failed to reveal additional comorbidity. Results: 5 male and 2 female patients with chronic hepatitis C experienced a rise in serum transaminases after commencement on treatment with pegylated interferon and ribavirin. They all achieved rapid and end of treatment virological responses. It is evident that in those patients whose treatment was temporarily or permanently aborted, the rise in transaminases rapidly improved and returned to baseline
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