Radiotherapy’s Indications and Limits in the Management of Bone Ewing's Sarcoma’s Children: About 22 Cases and Review of the Literature

Abstract

To study the indications and limits of radiotherapy in the treatment of bone Ewing's sarcoma’s children, we conducted a retrospective study of 22 cases collected over a period of 10 years from January 2011 to December 2020. The study took into account various clinical, radiological, therapeutic and evolutionary aspects of this pathology. The average age of patients was 11 years, with gender equality. The diagnostic approach was identical, based on clinical, radiological and histological data. Therapeutic management was based on chemotherapy, with local treatment combining radiotherapy with or without surgical resection of the tumor. Ewing's sarcoma is a relatively rare malignant tumor that grows mainly in bone and often has a large extension into soft tissue. All the bones of the skeleton can be affected, with a clear predominance of the lower limb (60% of cases). Medical imaging is essential for diagnosis as well as for therapeutic evaluation. While the diagnosis of certainty is currently based on histological and molecular biology data. Therapeutic management combines a multimodal approach including chemotherapy, surgery and radiotherapy. Nowadays the prognosis has improved thanks to the development of therapeutic methods.