Radiosynthesis of [123I]N‐(3‐iodoprop‐(2E)‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

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AbstractThe radiosynthesis of a novel tropane derivative [123I]KUC‐25019, [[123I];N‐(3‐iodoprop‐(2E)‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I‐labeling synthesis. The no‐carrier‐added 123I‐labeling has about 20% yield, the specific activity of [123I]KUC‐25019 is > 107 GBq/µmol and the radiochemical purity of [123I] KUC‐25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.