Radiosurgery in Lesional Epilepsy: Brain Tumors

Abstract

The purpose of this study was to examine the effects of different doses of radiation to the brain tissue immediately adjacent to tumors which were associated with epilepsy. From April 1992 to December 1995, 26 patients with medically intractable tumor epilepsy (mean duration 6.9 years, range: 1–27 years) have been treated with Gamma Knife radiosurgery (GKRS). Clinical and imaging controls were available for 24 patients with a mean follow-up of 2.25 years (range: 1–4.4 years). Tumor control had been achieved in all patients. The patients were divided into two groups according to the volume of tissue outside the tumor which had received 10 Gy or more. This volume was assessed by measuring the ratio of the tumor and the ratio of the volume within the isodose containing 10 Gy (10G/Tum ratio). 54 percent of all the 24 patients achieved an excellent result according to the Engel classification (class I or II). The patients were divided into two groups. In group I were 12 patients, and the 10G/Tum ratio was 3 or less. In group II there were 12 patients and the 10G/Tum ratio was more than 3. In group I the mean value for the 10G/Tum ratio was 2 (range 0.86 to 2.9). In group II the mean value of the ratio was 11.1 (range 3.13 to 63.2). In group I only 42% of patients achieved an excellent result compared with 66% in group II. Moreover, the location of the tumor had an effect on the results, in that temporal tumors were associated with excellent results in 64% of cases as opposed to 40% in extratemporal tumors. Finally, if the epilepsy had lasted for 2.5 years or less there were excellent results in 70% of patients, as opposed to 43% excellent results for patients who had suffered epilepsy for more than 2.5 years.