Abstract
SummaryThree compounds which differ widely in their chemical reactions with cellular constituents were found to sensitize Shigella flexneri Y6R, Escherichia coli B/r and E. coli BS-1 to the effects of ionizing radiation.The radiosensitivity of survivors from bacteria treated with toxic concentrations of these compounds and then washed was the same as untreated bacteria. However, bacteria treated with non-toxic concentrations of indane trione and acriflavine and then thoroughly washed were more resistant to the effects of u.v.-light.Since the bacteria were sensitized to ionizing radiation only in the presence of the free compounds, it was concluded that sensitization to ionizing radiation could be by means of an energy-transfer mechanism between the sensitizing compound and neighbouring but not bonded vital macromolecules. Alternatively sensitization may involve interaction between short-lived, radiation-induced radicals and the sensitizing compound.
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Schedule a callMore From: International journal of radiation biology and related studies in physics, chemistry, and medicine
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