Abstract
AbstractThe aliphatic amines, ω‐phenylpentylamine and its β‐methyl substituted analogue were synthesized from ω‐phenylpentanoic acid in 34.7% and 28.5% overall chemical yield respectively. γ‐Methyl‐ω‐phenylpentylamine was prepared from ω‐phenylbutyric acid in 39.5% overall chemical yield. Radioiodination of the amines with thallium trifluoroacetate and no‐carrier‐added [131I]‐NaI afforded the corresponding [131I]‐labelled amines in 30%, 28% and 36% radiochemical yield respectively and greater than 98% radiochemical purity (calculated specific activity 20 – 40 TBqmmol−1). The position of iodination was established by proton magnetic resonance to be para to the alkyl chain.
Published Version
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