Abstract
Objective: The aim of the present study is to assess the radiographic and immunohistochemical effect of strontium ranelate (SR) and metal substituted hydroxyapatite (MSHA) on the treatment of chronic periodontitis among diabetic rats Materials and Methods: The study involved ten adult male and female rice rats (1-month-old) weighting (250- 300g). After a 24-hour fast, a single intraperitoneal dose of freshly prepared alloxan was injected to induce diabetes. A month after the injection of alloxan, the rats were randomly assigned to one of the two treatment modalities: SR with gengigel or MSHA with gengigel. Digital periapical radiography was taken at baseline, a month after the injection of alloxan to see resorbed alveolar bone and after 3months post-operative surgery for radiographic assessment. The diabetic rats were sacrificed using an overdose of anesthesia, and gingival tissue samples were collected. The specimens were processed for hematoxylin and eosin (H & E) staining and immune stain for expression of matrix metalloproteinases 2 (MMP-2). Results: Digital periapical radiography showed an increase of nearly 0.37 mm in the height of the alveolar bone in the side of the SR group while the other side in the MSHA group increased by nearly 0.12 mm. A statistically significant reduction in the expression of MMP2 in the SR group as compared to the MSHA group was found upon comparing the immunohistochemical results of the 2 groups. Conclusion: Radiographic and immunohistochemical results showed that SR was a promising material in the treatment of periodontal diseases.
Highlights
Radiographic and immunohistochemical results showed that strontium ranelate (SR) was a promising material in the treatment of periodontal diseases
We found a various degrees of ulceration related to sulcular epithelium.The severity of the ulceration varied according to severity of the disease (Figure 6)
Using image analysis program for digital periapical radiography after 3 months of treatment showed that there was statistical increase in BG in strontium ranelate group (0.37 mm bone gain) as compared to metal substituted hydroxy apatite (0.12 mm bone gain).Radiographic findings showed that SR treated group showed more bone gain than metal substituted hydroxyapatite group These findings are in agree with Elgendy & Shoukheba, [26] who concluded that strontium ranelate 2% gel appears to be safe and may support periodontal wound healing/regeneration in intrabony periodontal defects induced in dogs without complications
Summary
Objective: The aim of the present study is to assess the radiographic and immunohistochemical effect of strontium ranelate (SR) and metal substituted hydroxyapatite (MSHA) on the treatment of chronic periodontitis among diabetic rats Digital periapical radiography results: comparing baseline and after 3 months measurements showed increase of nearly 0.37 mm in the height of the alveolar bone in the side of the group I (Strontium Ranelate) while the other side in the group II (Metal Substituted Hydreoxy Apatite) increased nearly 0.12mm in the height of the alveolar bone (Figure 3,4, Table 1).
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