Radiogenomics of breast cancer as new vector of interdisciplinary integration of radiation and molecular biological technologies (literature review)

Abstract

The review presents the latest data on the development of a new direction of interdisciplinary integration of radiation and molecular biological technologies ‘omi с s', including high technologies in the field of genomics, transcriptomics, proteomics and metabo-lomics, which are the basis of systems biology and the future of medicine. The integration of medical imaging and advances in genetics have created a new direction of research - radiogenomics, which is a key step in the development of omhs-technologies. Radiogenomics - phenotype imaging, computer vision - is an interdisciplinary integration of visual radiology and biological systems that study biomedical imaging involving phenotypic and genotypic parameters that reflect the molecular and genotypic basis of tissue from which to predict patient risk and outcomes. Coupled with state-of-the-art analytical software, quantitative and qualitative imaging biomarkers bring unprecedented insight into complex tumor biology and contribute to a deeper understanding of cancer development and progression. Using the latest advances in digital, information and molecular biological technology, is an active convergence of specialties radiologist and genetics, giving the opportunity at the stage of studying medical images of the breast to obtain information about the biological characteristics of the tumor molecular subtype of cancer, determining prognosis, evaluating risk of recurrence, which is important for the choice of adequate tactics of individual monitoring and selection of medical benefits. Development of visual symptom medical images of the breast, characteristic for different molecular subtypes of cancer, will contribute to more accurate diagnosis of different manifestations of cancer, the choice of adequate treatment tactics that increase the duration and preservation of the high quality of a woman s life.