Abstract
In this study, we report on the radical [ 18F]fluoroarylation of different olefins using 4-[ 18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[ 18F]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of 18F-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30–45% overall radiochemical yield starting from [ 18F]fluoride.
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