Abstract
Addition of lithium bis(methylenecyclopropyl)cuprates to acetoxy azetidinones gives methylenecyclopropyl azetidinones, which can be converted to various radical cyclisation precursors. Attempted 4- exo cyclisation of 3 led only to reduced product, while cyclisation of 5, using CuCl/bipy, gave a carbacephem, via a 5- exo cyclisation, but in low yield. Cyclisation of 6 and 7, however, gave novel tricyclic β-lactams, as the result of 7- endo cyclisation, in good yield, and a cyclisation of bromide 23 led to the tricyclic β-lactam 24, via a radical cascade sequence.
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