Abstract
Preface to Series vii Introduction ix Contributors xi 1. Theoretical Modeling of Radiation-Induced DNA Damage 1 Anil Kumar and Michael D. Sevilla 2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41 William A. Bernhard 3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69 Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. Richard Wagner 4. Reactivity of Nucleic Acid Sugar Radicals 99 Chryssostomos Chatgilialoglu 5. Pyrimidine Nucleobase Radical Reactivity 135 Marc M. Greenberg 6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163 Ryu Tashiro and Hiroshi Sugiyama 7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191 Kiyohiko Kawai and Tetsuro Majima 8. Radical Intermediates During Reductive Electron Transfer Through DNA 211 Reji Varghese and Hans-Achim Wagenknecht 9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239 Leon Sanche 10. Electronic-Affinic Radiosensitizers 295 Peter Wardman 11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325 Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov 12. Principles and Applications of Electrochemical Oxidation of Nucleic Acids 357 H. Holden Thorp and Julie M. Sullivan 13. DNA Damage Due to Diradical-Generating Cyclizations 389 Sean M. Kerwin 14. DNA Damage by Phenoxyl Radicals 421 Richard A. Manderville Index 445
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