Abstract
Several types of SARS-CoV-2 vaccine have been developed. However, the relationship between SARS-CoV-2 vaccine and radiation therapy (RT) is unclear. Recently, there have been some reports of radiation recall phenomenon (RRP) caused by a SARS-CoV-2 vaccine. We report a case of RRP after administration of the mRNA-1273 SARS-CoV-2 vaccine. A 51-year-old female was diagnosed with breast cancer (cT4N1M0, cStage IIIB) and underwent breast total mastectomy with axillary lymph node dissection after neoadjuvant chemotherapy. After mastectomy, the patient received RT with 50 Gy in 25 fractions. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred after RT. The patient had not started any new systemic medication after RT; however, the patient received the mRNA-1273 SARS-CoV-2 vaccine (Moderna) 1 month after the end of the initial RT. Seven days after vaccination, the patient had a skin reaction with burning sensation and redness. This skin reaction was induced in an area corresponding to the irradiation field of the chest wall. There was no skin reaction in areas other than that described. The reaction was cured within 1 week with topical hydrocortisone. This report is an interesting case report with a RPP after administration of the mRNA-1273 SARS-CoV-2 vaccine.
Highlights
SARS-CoV-2 vaccines have been developed by various companies including Pfizer-BioNTech, Moderna and AstraZeneca
Radiation recall phenomenon (RRP) is defined as a phenomenon in which an inflammatory response is induced in an area corresponding to the irradiation field by administering a specific drug to a patient who has a history of radiotherapy (RT) [1]
Since D'Angio reported RRP caused by D-actino maycin in 1959, various inducers have been reported [1]
Summary
SARS-CoV-2 vaccines have been developed by various companies including Pfizer-BioNTech, Moderna and AstraZeneca. The long-term efficacy and safety of all vaccines are not clear, and their relationship with radiation therapy (RT) is unclear. Radiation recall phenomenon (RRP) is defined as a phenomenon in which an inflammatory response is induced in an area corresponding to the irradiation field by administering a specific drug to a patient who has a history of radiotherapy (RT) [1]. RRP does not develop slowly as in radiation dermatitis but develops rapidly. There are some reports of the RRP caused by the SARSCoV-2 vaccine [2,3,4]. To the best of our knowledge, this is the first report of RRP after administration of a mRNA-1273 SARS-CoV-2 vaccine (manufactured by Moderna)
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