Abstract
Among the several factors involved in the therapy of metastatic thyroid cancer with massive doses of I131, the dose of radiation delivered to lesions and to normal tissues is of particular importance (1). At present, the tissue doses arising from the presence of radio-elements in the body cannot be measured directly in situ by ionization methods, but reasonable estimates can be obtained by indirect means. Although these estimates are less precise than those available to conventional radiation therapy, they provide, nevertheless, information which should be useful to the establishment of a rational administration of the isotope and to the correct interpretation of the patient's clinical response. The Tumor Dose It has been shown (2) that the beta radiation dose and the I131 concentration in tissue are related by the following formulae: In these expressions, Te is the effective half-life in days of I131 in the tissue under consideration, i.e., the half-life resulting from both radioactive decay and physiolo...
Published Version
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