Abstract
Urinary bladder cancer (UBC) has a high incidence rates in many southern and eastern European countries, in parts of Africa and the Middle East, and in North America. It exhibits a wide variety of histological types that goes from less aggressive to rapid-growing ones. In order to compare the different presentations, etiologies, and prognoses among racial groups, including NHW (non-Hispanic white), HW (Hispanic white), blacks, and API (Asian and Pacific Islander), we analyzed the UBC patients diagnosed between 1973 and 2014 using SEER (Surveillance, Epidemiology, and End Results) database. Patient characteristics, age-adjusted incidence rates, and survival were compared across races. There are significant racial differences in patients’ characteristics, including gender, marital status, age at diagnosis, treatment strategies, grade, stage, survival time, and so on. Overall, non-Hispanic whites have the highest incidence rate, followed by blacks, Hispanic whites, and APIs. In the analysis of survival, significant racial differences exist when stratified by gender, age group, histological type, stage, location and treatment strategies. Racial differences exist among UBC patients in the United States in terms of characteristics, incidence, and survival. Future studies may collect and analyze more data for comprehensive description and interpretation of the racial differences.
Highlights
Study on racial differences among cancer patients have attracted extensive attention[1,2,3]
This study aims to comprehensively describe the racial differences among Urinary bladder cancer (UBC) patients in the United States in terms of patients’ characteristics, clinical-pathologic features, incidence rates, and survival rates by analyzing the SEER database
Scosyrev and others[18] only compared blacks and whites. They found that African American patients present with less favorable tumor characteristics compared with white patients, accounting for a much higher UBC mortality experienced by these groups
Summary
Study on racial differences among cancer patients have attracted extensive attention[1,2,3]. Transitional Cell Carcinoma (TCC) is the most common histological type of primary UBC, which comprises more than 90% of all bladder tumors[6]. The incidence rate of bladder squamous cell carcinoma in bladder malignancies worldwide varies widely It is usually associated with the chronic urinary infection caused by schistosoma haematobium ( known as schistosomiasis or bilharzia). This study aims to comprehensively describe the racial differences among UBC patients in the United States in terms of patients’ characteristics, clinical-pathologic features, incidence rates, and survival rates by analyzing the SEER database. Researches on racial differences among cancer patients have attracted extensive attention[1,2,3], but the discussion on UBC remains scarce. We compare a wider spectrum of racial groups, including NHW (non-Hispanic white), HW (Hispanic white), blacks, and API (Asian and Pacific Islander), and analyze multiple aspects, including patients’ characteristics, clinical-pathological features, incidence rate, and survival rate
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