Abstract
Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. Methods: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020. Results: A final total of 20 studies included in this review. Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.
Highlights
Humans have a long history of viral infections
This review review investigates the new derivatives that that are are showing This investigates the new quinoxaline quinoxaline derivatives showing promise promise as as antiviral antiviral drugs as part of our program focused on the anti-infectious activity of quinoxaline derivatives
Quinoxaline represent an important class of nitrogen-containing heterocycles with a wide range of potential biological activities
Summary
Humans have a long history of viral infections. For some viral diseases, vaccines and antiviral drugs have made it possible to prevent infections or have helped those infected to recover. Recent antiviral drug development has led to the discovery of effective new treatments to control Human Immunodeficiency. Several viruses have jumped from animals to humans triggering sizable outbreaks. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold
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