Abstract
Quinoxalines, a class of N-heterocyclic compounds, are important biological agents, and a significant amount of research activity has been directed towards this class. They have several prominent pharmacological effects like antifungal, antibacterial, antiviral, and antimicrobial. Quinoxaline derivatives have diverse therapeutic uses and have become the crucial component in drugs used to treat cancerous cells, AIDS, plant viruses, schizophrenia, certifying them a great future in medicinal chemistry. Due to the current pandemic situation caused by SARS-COVID 19, it has become essential to synthesize drugs to combat deadly pathogens (bacteria, fungi, viruses) for now and near future. Since quinoxalines is an essential moiety to treat infectious diseases, numerous synthetic routes have been developed by researchers, with a prime focus on green chemistry and cost-effective methods. This review paper highlights the various synthetic routes to prepare quinoxaline and its derivatives, covering the literature for the last two decades. A total of 31 schemes have been explained using the green chemistry approach, cost-effective methods, and quinoxaline derivatives’ therapeutic uses.
Highlights
IntroductionQuinoxaline is defined as a weakly basic bi-cyclic compound C8H6N2, having fused. Qumionleocxulaesl2in60e41i0s55defined as a weakbleynbzaesniec bani-dcypcylircaczoinmeproinugnsd
An efficient method was established by Allan et al [45], which is an acid-catalyzed reaction for the synthesis of 4-aryl substituted pyrrolo[1,2-a] quinoxalines (24)
It is indispensable to expand this area of study, to prepare quinoxaline derivatives via the thiation of novel 3-phenylquinoxalin2(1H)-one to get potent anticancer drugs
Summary
Quinoxaline is defined as a weakly basic bi-cyclic compound C8H6N2, having fused. Qumionleocxulaesl2in60e41i0s55defined as a weakbleynbzaesniec bani-dcypcylircaczoinmeproinugnsd. Using Bentonite Clay K-10 The green organic synthesis approach is gaining much ground for research because it is environment friendly, and limitations like harsh reaction conditions, expensive reagents, and low Molecules 2020, 25, x FOR PEER REVIEW yield can be eliminated. Hasaninejad et al [20] to synthesize quinoxaline derivatives by using bentonite clay K-10 at room temperature. Clay, with 3a short reaction t2i0me of 20 min. Betonite clay6K-10 ovMeerClNays the wa3y5 for green chem92istry organic synthesis, with exceptionally mild c7onditionTsHsFuch as sho30rt reaction time,8h9 igh yield, low cost, and simple experimental and isolation procedures. Betonite clay K-10 overlays the way for green chemistry organic synthesis, with exceptionally mild conditions such as short reaction time, high yield, low cost, and simple experimental and isolation procedures.
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