Abstract
Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ( 1 ) and its glycoside derivatives 2 and 3 . The other constituents isolated include f -amyrin, 3 g -acetyl ursolic acid and a mixture of oleanolic and ursolic acid and g -sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds 2 and 3 were, respectively, identified as quinovic acid 3- O -[ g - d -glucopyranoside] (quinovin glycoside C) and quinovic acid 3- O -[ g - d -quinovopyranoside]-27- O -[ g - d -glucopyranosyl] ester. Compounds 1 and 2 showed significant inhibitory activity against snake venom phosphodiesterase I.
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