Quick Reference Psychosomatic Medicine

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Back to table of contents Previous article Next article CLINICAL SYNTHESISFull AccessQuick Reference Psychosomatic MedicineMed-Psych Drug-Drug Interactions Update An Overview of Psychotropic Drug-Drug InteractionsPublished Online:1 Jul 2009https://doi.org/10.1176/foc.7.3.foc347AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractSource: Sandson NB, Armstrong SC, Cozza KL: Med-Psych Drug-Drug Interactions Update An Overview of Psychotropic Drug-Drug Interactions. Psychosomatics 2005;46:464–494. Reprinted with permission. Please refer to the full article for specific citations of each interaction.The psychotropic drug-drug interactions most likely to be relevant to psychiatrists' practices are examined. The metabolism and the enzymatic and P-glycoprotein inhibition/induction profiles of all antidepressants, antipsychotics, and mood stabilizers are described; all clinically meaningful drug-drug interactions between agents in these psychotropic classes, as well as with frequently encountered nonpsychotropic agents, are detailed; and information on the pharmacokinetic/pharmacodynamic results, mechanisms, and clinical consequences of these interactions is presented. Although the range of drug-drug interactions involving psychotropic agents is large, it is a finite and manageable subset of the much larger domain of all possible drug-drug interactions. Sophisticated computer programs will ultimately provide the best means of avoiding drug-drug interactions. Until these programs are developed, the best defense against drug-drug interactions is awareness and focused attention to this issue.Appendix 1. Significant Drug-Drug Interactions Involving AntidepressantsAppendix 1. Significant Drug-Drug Interactions Involving AntidepressantsAppendix 1. Significant Drug-Drug Interactions Involving AntidepressantsEnlarge tableAppendix 2. Significant Drug-Drug Interactions Involving AntipsychoticsAppendix 2. Significant Drug-Drug Interactions Involving AntipsychoticsAppendix 2. Significant Drug-Drug Interactions Involving AntipsychoticsEnlarge tableAppendix 3. Significant Drug-Drug Interactions Involving Mood StabilizersAppendix 3. Significant Drug-Drug Interactions Involving Mood StabilizersAppendix 3. Significant Drug-Drug Interactions Involving Mood StabilizersEnlarge tableAppendix 4. Significant Drug-Drug Interactions Involving Other Psychotropic Agents and Nonpsychotropic AgentsAppendix 4. Significant Drug-Drug Interactions Involving Other Psychotropic Agents and Nonpsychotropic AgentsAppendix 4. Significant Drug-Drug Interactions Involving Other Psychotropic Agents and Nonpsychotropic AgentsEnlarge table FiguresReferencesCited byDetailsCited byNone Volume 7Issue 3 Summer 2009Pages 347-364Psychosomatic Medicine PDF download