Abstract
overly academic or irrelevant to actual patient care. In fact, DDIs have an enormous impact on patient care, and the pervasively poor recognition of DDIs is a major part of the problem. DDIs are an especially important issue for psychiatrists, because many commonly used psychotropic agents have abundant P-450 and P-glycoprotein effects that may affect the blood levels of other drugs (2,3). Similarly, many of the nonpsychotropic drugs that our patients take can significantly increase or decrease the blood levels of most psychotropic agents. To treat patients in a competent and safe manner, some awareness of the DDI issue and some means of detecting DDIs are essential.
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