Abstract
There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS-CoV-2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS-CoV-2. This article is protected by copyright. All rights reserved.
Highlights
The SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared with other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2
The flat and nonsunken surface of the sialic acid‐ binding domain of SARS‐CoV‐2 spike protein (S protein) conflicts with the general adaptation and survival pattern observed for all other CoVs
Unlike RaTG13, SARS‐CoV‐2 recombination presumably occurred between the S1/S2 domains of S protein enabling host furin protease utilization
Summary
Follow this and additional works at: https://scholarcommons.usf.edu/usf_fcrc_all. Scholar Commons Citation Seyran, Murat; Pizzol, Damiano; Adadi, Parise; El‐Aziz, Tarek M.; Hassan, Sk. Sarif; Soares, Antonio; Kandimalla, Ramesh; Lundstrom, Kenneth; Tambuwala, Murtaza; Aljabali, Alaa A. A.; Lal, Amos; Azad, Gajendra K.; Choudhury, Pabitra P.; Uversky, Vladimir N.; Sherchan, Samendra P.; Uhal, Bruce D.; Rezaei, Nima; and Brufsky, Adam M., "Questions Concerning the Proximal Origin of SARS‐CoV‐2" (2021). USF Libraries Florida COVID Research Collection publications. Authors Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek M. El‐Aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Kenneth Lundstrom, Murtaza Tambuwala, Alaa A. This article is available at Scholar Commons: https://scholarcommons.usf.edu/usf_fcrc_all/109
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