Quercetine influence on the resological properties of blood for elderly patients with metabolic syndrome

Abstract

The aim – to study the effects of quercetin on the functional status of platelets and blood viscosity in elderly patients with metabolic syndrome (MS).Materials and methods. Fifty patients with MS at the age of 60–75 years, who were equally distributed into the experimental and control groups, were examined. Patients of the experimental group received quercetin for 3 months («Quertin», PJSC SIC «Borshchahivskiy CPP», Ukraine) 80 mg 3 times a day. The control group received placebo for the same period of time. Before and after the treatment, MS criteria, platelet aggregation ability, blood viscosity and serum lipid levels were assessed.Results and discussion. After quercetin course, the rheological blood properties improved, that is its viscosity, spontaneous and induced platelet aggregation decreased. A statistically significant decrease in serum total cholesterol and LDL cholesterol levels was noted. Correlation analysis showed that an improvement in blood viscosity occurred due to favourable changes in the lipid spectrum and a decrease in the aggregation ability of blood cells.Conclusions. The obtained results indicate that in elderly patients with metabolic syndrome a course (within 3 months) use of quercetin reduces manifestations of dyslipidemia, increases spontaneous and induced platelet aggregation, contributes to an increase in the erythrocyte deformability index, which together lead to the decrease of blood viscosity, as one of the risk factors for the development of complications in metabolic syndrome.