Abstract
Simple SummaryThe biological activity of quercetin is diverse, particularly antioxidant, antimicrobial, and antibacterial. The impacts of quercetin nutritional supplementations on growth performance, humoral immunity, gut microbiota and mRNA in broiler chickens were recorded.Quercetin was fed to groups of broiler chickens at concentrations of 200, 400, and 800 ppm, and a control group was supplemented with a basal diet. Results revealed that quercetin dietary supplementation numerically improved the growth performance traits and significantly increased (p < 0.05) the European production efficiency factor (EPEF) in the 200 ppm group. The total coliforms and Clostridium perfringens were decreased (p < 0.05) in quercetin-supplemented groups. Conversely, Lactobacillus counts were increased (p < 0.05), due to improvement of the gut microbiota environment in quercetin-supplemented groups. Moreover, the mRNA expression of intestinal Cu/Zn-superoxide dismutase (SOD1), glutathione peroxidase (GSH-Px) and nutritional transporters, including glucose transporter 2 (GLUT2), peptide transporter 1 (PEPT1), and fatty acid synthase (FAS) genes, were significantly upregulated in quercetin-supplemented groups. Quercetin enhanced intestinal morphometry. We can suggest quercetin supplementation in broiler chickens by levels between 200 and 400 ppm to enhance their development and gut environment.
Highlights
Introduction distributed under the terms andThe microbiome plays a major role in the gastrointestinal tract health, immune system, and productivity of broiler chickens [1]
The research was endorsed by the Local Experimental Animal Care Committee of the University of Damanhour, Egypt, Faculty of Veterinary Medicine (VMD: 15/2018)
Chicks were allocated into control group 1; group 2 (Q200), group 3 (Q400), and group 4 (Q800) were fed a commercial basal diet containing 200, 400, and 800 ppm quercetin
Summary
The microbiome plays a major role in the gastrointestinal tract health, immune system, and productivity of broiler chickens [1]. The link between intestinal health and overall health is raised by the quality of feed consumed by broiler chickens [2]. Exogenous enzymes to the diet of broiler chickens to increase their efficiency and productivity [3,4,5,6,7,8]. Flavonols can regulate feed intake, contribute to eubiosis, and exhibit antimicrobial, immunomodulatory, anti-inflammatory, and antioxidant properties in monogastric animals [9]. Anti-inflammatory, antimicrobial, anti-obesity, anti-hypercholesterolemic, antioxidant, antiaging, and anticancer agent [11]. Quercetin is generally one of the most commonly used bioflavonoids for metabolic and inflammatory diseases [12]
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