Abstract
Background Quercetin's role in the homeostasis of certain trace elements in dyslipidemia induced in mice was assessed. Methods Forty BALB/c mice were allocated into 4 groups as follows: control; HFD, received fat diet; HFD + Q group, received HFD +500 mg/L quercetin; and blank control (Q)—normal food + 500 mg/L quercetin in drinking water. Results By analyzing the values of total proteins, albumins, cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and the levels of several trace elements in blood and organs, we perceived a statistically significant increase (∗∗, p < 0.01) of TP, ALB, TC, TGE, and LDL-c. A nonsignificant decrease was ascertained to HDL-c value in the HFD and quercetin groups (p > 0.05). In the HFD group, all analyzed elements in the kidney and spleen increased, also Cu, Li, Mg, Mn, Pb, and of B, Ba, Cr, Cd, Cu, Fe, Li, Mn, Ni, Pb, and Zn in the heart increased, but furthermore, Ag, B, Ba, Cd, Cr, Fe, Ni, and Zn in blood, Ag and Zn in the liver, and Cd in the spleen decreased. In the HFD group who received quercetin, elements (except B) were decreased in kidney and liver, also increased Ag, Ba, Cr, Fe, Li, Ni, Zn in blood, but similarly, Ag, B, Ba, Cd, Cu, Mn, and Pb declined in the spleen and heart. Conclusions Results proved the quercetin beneficial role.
Highlights
Dyslipidemia is part of metabolic syndrome and represents mainly a disorder of lipoprotein metabolism characterized by abnormalities of the following markers: increased lowdensity lipoprotein cholesterol (LDL-c), triglycerides (TGE), total cholesterol (TC), and decreased high-density lipoprotein cholesterol (HDL-c) [1,2].Dyslipidemia is one of the factors that can be modified to prevent the development of cardiovascular diseases, atherosclerosis, stroke, and type 2 diabetes [1,3–8].e 3, 3′, 4′, 5, 7-pentahydroxyflavone, known as quercetin, is a flavonoid that could be found widely in a large variety of fruits and vegetables [9–11].Research on human and animal subjects has shown that quercetin has beneficial effects in cardiovascular disease, Evidence-Based Complementary and Alternative Medicine nervous system disease, and liver and kidney disease [9,12], since it possesses anti-inflammatory, antihypercholesterol, antisclerotic, and antiobesity properties [13,14]
Total cholesterol (TC) significantly (p < 0.001) increased in high-fat diet (HFD) mice compared to controls (+108.40%) and significantly decreased (p < 0.001) when quercetin was administered to mice (-34.86%)
We observed a significant increase in total protein (TP) and ALB in the HFD group compared to the control and a significant decrease when quercetin was administered. e increase was directly correlated with the levels of TC, TGE, and LDL-c and indirectly correlated with HDL-c level
Summary
Dyslipidemia is part of metabolic syndrome and represents mainly a disorder of lipoprotein metabolism characterized by abnormalities of the following markers: increased lowdensity lipoprotein cholesterol (LDL-c), triglycerides (TGE), total cholesterol (TC), and decreased high-density lipoprotein cholesterol (HDL-c) [1,2].Dyslipidemia is one of the factors that can be modified to prevent the development of cardiovascular diseases, atherosclerosis, stroke, and type 2 diabetes [1,3–8].e 3, 3′, 4′, 5, 7-pentahydroxyflavone, known as quercetin, is a flavonoid that could be found widely in a large variety of fruits and vegetables [9–11].Research on human and animal subjects has shown that quercetin has beneficial effects in cardiovascular disease, Evidence-Based Complementary and Alternative Medicine nervous system disease, and liver and kidney disease [9,12], since it possesses anti-inflammatory, antihypercholesterol, antisclerotic, and antiobesity properties [13,14]. The aim of this study (part of a larger one on this topic) was to find whether dietary quercetin supplementation plays a role in the homeostasis of trace elements in mice with induced dyslipidemia. In the HFD group, all analyzed elements in the kidney and spleen increased, Cu, Li, Mg, Mn, Pb, and of B, Ba, Cr, Cd, Cu, Fe, Li, Mn, Ni, Pb, and Zn in the heart increased, but Ag, B, Ba, Cd, Cr, Fe, Ni, and Zn in blood, Ag and Zn in the liver, and Cd in the spleen decreased. In the HFD group who received quercetin, elements (except B) were decreased in kidney and liver, increased Ag, Ba, Cr, Fe, Li, Ni, Zn in blood, but Ag, B, Ba, Cd, Cu, Mn, and Pb declined in the spleen and heart.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call