Abstract
Summary The influence of 30 substituted aniline derivatives on the autotrophic growth of Chlorella vulgaris suspensions was investigated. Isoactive concentrations inhibiting the growth by 50% vary from 4.5 - 10-3 to 4.5 - 10-5 M within the studied group of substances. Isoactive inhibitory values of pc5o were determined from dosage-effectivity relations and used as activity parameters for structure-activity correlations. Simple regressions equations are reported, discussed and compared with analogous QSAR of earlier tested series. Displays of the pc5o values as function of various series of hydrophobic substituent constants showed linear relations with high correlation coefficients contrary to electronic substituent parameters. Ortho-substituted derivatives were less active and gave functions. With exception of NH2-, C02H-, N02- and OH-substituted aniline derivatives could be calculated a simple QSAR for the autotrophic growth inhibition of Chlorella vulgaris suspensions.
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