Abstract
The influence of 14 monosubstituted 4-arylsemicarbazides on the heterotrophic growth of Chlorella vulgaris suspensions was studied. In all cases of inhibition we obtained a typical dependency between activities and concentrations of the semicarbazides. Isoactive concentrations inhibiting algae suspension growth by 50% vary from 2 × 10 -3 M to 1 · 10 -4 M within the group of substances studied. Displays of the pc 50 1 ) values as a function of various series of hydrophobic substituent constants showed linear relations with high correlation coefficients, in contrast to electronic substituent parameters. Ortho -substituted derivatives were less active. With the exception of 4-(2-hydroxyphenyl)-semicarbazide we suggest a simple quantitative structure - activity relation for the growth inhibition of heterotrophic Chlorella vulgaris suspension, which corresponds with earlier results obtained with autotrophic Chlorella vulgaris suspensions.
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