Quantitative sensory and motor measures detect change over time and correlate with walking speed in individuals with multiple sclerosis

Abstract

BackgroundImpairments of sensation, strength, and walking are common in multiple sclerosis (MS). The relationship among these abnormalities and how they change over time remains unclear. ObjectiveTo determine the extent that quantitative lower extremity sensory and motor measures detect abnormalities over time, relate to global disability, and to walking speed in individuals with MS. MethodsThis prospective, longitudinal analysis evaluated 136 MS subjects. Measures included measures of leg strength, sensation, the Expanded Disability Status Scale(EDSS) and timed 25-foot walk test (T25FW). Mixed effects regression models were used. ResultsOur cohort׳s mean age is 44.3±10.8 years (mean±SD), EDSS score range 0–7.5, 66% were females, and follow-up time was 2.1±1.2 years. Strength significantly changed over time; the RRMS group demonstrated the greatest changes in ADF (3.3lbs/yr) while the PPMS group showed significant HF changes (−2.1lbs/yr). Walking speed was affected most by HF, especially in the weakest individuals (HF<20lbs); T25FW increased by 0.20s for each 1lb loss (p=0.001). Likewise T25FW changed by 0.19s for each 1lb change in ADF (p<0.01). ConclusionQuantitative measures detected changes in sensation and strength over time, despite a stable respective functional systems scores of the EDSS. Quantitative measurement tools may improve the sensitivity of disability measures in MS and further investigation of these tools as outcomes in future clinical trials of rehabilitative and neuroreparative interventions is warranted.