Abstract
Acousto-optic imaging is a dual-wave modality that combines ultrasound with diffuse light to achieve deep-tissue imaging of optical contrast with the spatial resolution of ultrasound. While substantial progress has been made in recent years in detecting and imaging optical inhomogeneities in highly scattering media based on the acousto-optic response, quantitative measurement of subsurface optical properties remains difficult. A technique for the local and quantitative measure of the optical properties of turbid media, referred to as pressure contrast acousto-optic imaging, is presented. In this approach, the acousto-optic signals elicited by ultrasound pulses at two different peak pressures are measured, and the ratio of the amplitudes of these two signals determined. The resulting pressure ratio, once calibrated for a given set of pressure pulses, is found to give a direct measure of the optical transport mean free path of the interaction region between the light and sound. Measurements of the transport mean free path of inclusions buried in diffuse tissue phantoms, with no a priori knowledge of the optical properties of the phantom in which the inclusion is embedded or sample dimensions, are demonstrated. [Work supported by the Center for Subsurface Sensing and Imaging Systems (NSF ERC Award No. EEC-9986821).]
Published Version
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