Quantitative parameter reconstruction from optical coherence tomographic data

Abstract

Quantitative tissue information, like the light scattering properties, is considered as a key player in the detection of cancerous cells in medical diagnosis. A promising method to obtain these data is optical coherence tomography (OCT). In this article, we will therefore discuss the refractive index reconstruction from OCT data, employing a Gaussian beam based forward model. We consider in particular samples with a layered structure, meaning that the refractive index as a function of depth is well approximated by a piecewise constant function. For the reconstruction, we present a layer-by-layer method where in every step the refractive index is obtained via a discretized least squares minimization. For an approximated form of the minimization problem, we present an existence and uniqueness result. The applicability of the proposed method is then verified by reconstructing refractive indices of layered media from both simulated and experimental OCT data.