Abstract
Technological advances in magnetic resonance imaging (MRI) and computed tomography (CT), including higher spatial and temporal resolution, have made the prospect of performing absolute myocardial perfusion quantification possible, previously only achievable with positron emission tomography (PET). This could facilitate integration of myocardial perfusion biomarkers into the current workup for coronary artery disease (CAD), as MRI and CT systems are more widely available than PET scanners. Cardiac PET scanning remains expensive and is restricted by the requirement of a nearby cyclotron. Clinical evidence is needed to demonstrate that MRI and CT have similar accuracy for myocardial perfusion quantification as PET. However, lack of standardization of acquisition protocols and tracer kinetic model selection complicates comparison between different studies and modalities. The aim of this overview is to provide insight into the different tracer kinetic models for quantitative myocardial perfusion analysis and to address typical implementation issues in MRI and CT. We compare different models based on their theoretical derivations and present the respective consequences for MRI and CT acquisition parameters, highlighting the interplay between tracer kinetic modeling and acquisition settings.
Highlights
Myocardial perfusion imaging (MPI) is commonly used to investigate myocardial ischemia
The aim of this study is to provide insight into the tracer kinetic models in absolute myocardial perfusion quantification, and their implementation requirements for computed tomography (CT) and magnetic resonance imaging (MRI)
These modeling techniques have been successfully applied in positron emission tomography (PET) myocardial perfusion imaging with different tracers, including 13N-ammonia and 82Rb-rubidium [33]
Summary
Myocardial perfusion imaging (MPI) is commonly used to investigate myocardial ischemia. Presence of regions with normal perfusion is essential for this method to work This is a limitation for diagnosis of patients with multivessel disease or balanced ischemia [2]. In PET, time-resolved acquisition of the first-pass of tracer uptake and direct quantification of tracer concentration were developed With those parameters quantified, tracer kinetic modeling (1-compartment or 2-compartment modeling) could be applied to produce independent estimates of perfusion in stress and rest, known as absolute perfusion measurement (mL/g/min). Tracer kinetic modeling (1-compartment or 2-compartment modeling) could be applied to produce independent estimates of perfusion in stress and rest, known as absolute perfusion measurement (mL/g/min) This technique has been validated using microsphere comparison [2,3,4]. A further aim was to analyze the factors that influence myocardial perfusion quantification
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
