Abstract
The quantitative histological distribution of inorganic and labile-ester phosphorus compounds in the adrenal gland of the male albino rat was studied. Subcutaneous injection of 25 mg. ACTH per kg. 3 hours prior to sacrifice lowered labile-ester phosphorus (predominantly ATP) in the fasciculata and elevated this fraction in the reticular-medullary border zone and medulla. Inorganic phosphorus was more uniformly distributed throughout the zones and the ACTH treatment produced some increase in all regions except outer fasciculata. Analysis of whole-gland homogenates prepared from adrenals of untreated animals killed at noon and at midnight revealed a considerable decrease in labile-ester and a significant increase in inorganic phosphorus at midnight. Injection of ACTH largely abolished these day-night differences by decreasing the values of the former and increasing those of latter in the noon group. A series of subcutaneous cortisone injections (7 mg. cortisone acetate/kg, daily for 2 weeks) produced signif...
Published Version
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