Abstract

1. 1. An immunochemical method for the estimation of albumin and gamma globulin in cerebrospinal fluid is outlined. 2. 2. Normal values for albumin and gamma globulin are presented. 3. 3. In fifteen of sixteen cases of neurosyphilis, increases in gamma globulin were found. The highest values were found in those patients with active neurosyphilis and the lowest in patients who had shown a favorable response to therapy. 4. 4. Eight of fourteen patients with multiple sclerosis showed an increased spinal fluid gamma globulin. 5. 5. Data on cerebrospinal fluid albumin and gamma globulin in a variety of other diseases are presented.

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