Abstract
The first suggestion that antibody might play a role in multiple sclerosis (MS) was the discovery of a selective increase in cerebrospinal fluid (CSF) gamma globulin in MS patients, as demonstrated by Tiselius moving-boundary electrophoresis [15]. This abnormality is not limited to MS; elevation of CSF gamma globulin, and the more recently described oligoclonal pattern in the gamma globulin region of MS CSF also occur in a variety of acute and chronic infections of the central nervous system (CNS).
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